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OALib Journal期刊

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A Pathogenic Potential of Acinetobacter baumannii-Derived Membrane Vesicles
Jong Suk Jin,Dong Chan Moon,Chi-Won Choi,Seung-Il Kim
Journal of Analytical Science & Technology , 2011,
Abstract: Acinetobacter baumannii secretes outer membrane vesicles (OMVs). A. baumannii OMVs deliver many virulence factors to host cells and then induce cytotoxicity and innate immune response. OMVs secreted from bacteria contribute directly to host pathology during A. baumannii infection.
Sequentially Vapor-Grown Hybrid Perovskite for Planar Heterojunction Solar Cells
Chan-Gyu Park,Dong-Won Kang,Fatma Pinar Gokdemir,Sungjae Na,Taeho Moon,Won-Gyu Choi
- , 2018, DOI: 10.1186/s11671-017-2401-5
Abstract: The online version of this article (10.1186/s11671-017-2401-5) contains supplementary material, which is available to authorized users
Research: Antimicrobial resistance of Pasteurella multocida strains isolated from pigs between 2010 and 2016
Bang-Hun Hyun,Dong-Chan Moon,Suk-Kyung Lim,Yoon-Hee Oh,Young Ju Lee
- , 2018, DOI: 10.1136/vetreco-2018-000293
Abstract:
Nuclear Translocation of Acinetobacter baumannii Transposase Induces DNA Methylation of CpG Regions in the Promoters of E-cadherin Gene
Dong Chan Moon, Chul Hee Choi, Su Man Lee, Jung Hwa Lee, Seung Il Kim, Dong Sun Kim, Je Chul Lee
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0038974
Abstract: Nuclear targeting of bacterial proteins has emerged as a pathogenic mechanism whereby bacterial proteins induce host cell pathology. In this study, we examined nuclear targeting of Acinetobacter baumannii transposase (Tnp) and subsequent epigenetic changes in host cells. Tnp of A. baumannii ATCC 17978 possesses nuclear localization signals (NLSs), 225RKRKRK230. Transient expression of A. baumannii Tnp fused with green fluorescent protein (GFP) resulted in the nuclear localization of these proteins in COS-7 cells, whereas the truncated Tnp without NLSs fused with GFP were exclusively localized in the cytoplasm. A. baumannii Tnp was found in outer membrane vesicles, which delivered this protein to the nucleus of host cells. Nuclear expression of A. baumannii Tnp fused with GFP in A549 cells induced DNA methylation of CpG regions in the promoters of E-cadherin (CDH1) gene, whereas the cytoplasmic localization of the truncated Tnp without NLSs fused with GFP did not induce DNA methylation. DNA methylation in the promoters of E-cadherin gene induced by nuclear targeting of A. baumannii Tnp resulted in down-regulation of gene expression. In conclusion, our data show that nuclear traffic of A. baumannii Tnp induces DNA methylation of CpG regions in the promoters of E-cadherin gene, which subsequently down-regulates gene expression. This study provides a new insight into the epigenetic control of host genes by bacterial proteins.
Estimations of the lethal and exposure doses for representative methanol symptoms in humans
Chan-Seok Moon
- , 2017, DOI: 10.1186/s40557-017-0197-5
Abstract: Exposure dose and effects of urinary biological indices of methano
Acinetobacter baumannii Secretes Cytotoxic Outer Membrane Protein A via Outer Membrane Vesicles
Jong Sook Jin,Sang-Oh Kwon,Dong Chan Moon,Mamata Gurung,Jung Hwa Lee,Seung Il Kim,Je Chul Lee
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0017027
Abstract: Acinetobacter baumannii is an important nosocomial pathogen that causes a high morbidity and mortality rate in infected patients, but pathogenic mechanisms of this microorganism regarding the secretion and delivery of virulence factors to host cells have not been characterized. Gram-negative bacteria naturally secrete outer membrane vesicles (OMVs) that play a role in the delivery of virulence factors to host cells. A. baumannii has been shown to secrete OMVs when cultured in vitro, but the role of OMVs in A. baumannii pathogenesis is not well elucidated. In the present study, we evaluated the secretion and delivery of virulence factors of A. baumannii to host cells via the OMVs and assessed the cytotoxic activity of outer membrane protein A (AbOmpA) packaged in the OMVs. A. baumannii ATCC 19606T secreted OMVs during in vivo infection as well as in vitro cultures. Potential virulence factors, including AbOmpA and tissue-degrading enzymes, were associated with A. baumannii OMVs. A. baumannii OMVs interacted with lipid rafts in the plasma membranes and then delivered virulence factors to host cells. The OMVs from A. baumannii ATCC 19606T induced apoptosis of host cells, whereas this effect was not detected in the OMVs from the ΔompA mutant, thereby reflecting AbOmpA-dependent host cell death. The N-terminal region of AbOmpA22-170 was responsible for host cell death. In conclusion, the OMV-mediated delivery of virulence factors to host cells may well contribute to pathogenesis during A. baumannii infection.
A 5-year change of knowledge and willingness by sampled respondents to perform bystander cardiopulmonary resuscitation in a metropolitan city
Dong Eun Lee,Hyun Wook Ryoo,Jae Yun Ahn,Jung Bae Park,Jung Ho Kim,Kyung Woo Lee,Sang-chan Jin,Sungbae Moon
- , 2019, DOI: 10.1371/journal.pone.0211804
Abstract:
Distribution Analysis of Twelve Mycotoxins in Corn and Corn-Derived Products by LC-MS/MS to Evaluate the Carry-Over Ratio during Wet-Milling
Chan Lee,Dong-Ho Kim,Ji-Young Moon,Jin-Ah An,Juhee Park,Soo-Hyun Chung,Young-Woo Kim
- , 2018, DOI: 10.3390/toxins10080319
Abstract:
Overgrowth of the lower limb after treatment of developmental dysplasia of the hip: incidence and risk factors in 101 children with a mean follow-up of 15 years
Chan Yoon,Chang Ho Shin,Chin Youb Chung,Dong Ook Kim,In Ho Choi,Moon Seok Park,Tae-Joon Cho,Won Joon Yoo
Acta Orthopaedica , 2020, DOI: https://doi.org/10.1080/17453674.2019.1688485
Abstract: Background and purpose — There are few studies on overgrowth of the affected limb after treatment of developmental dysplasia of the hip (DDH). We investigated the incidence of overgrowth and its risk factors in DDH patients. Patients and methods — 101 patients were included in this study. Overgrowth was defined by 2 criteria: when the height of the femoral head of the affected side was higher than that of the contralateral side by more than 10？mm, or by more than 15？mm. The potential risk factors of distinct overgrowth were retrospectively examined using multivariable analysis. Results — When overgrowth was defined as femoral head height difference (FHHD) > 10？mm, its incidence was 44%, and only femoral osteotomy was identified as a significant risk factor with a relative risk (RR) of 1.6 (95% confidence interval [CI] 1.0–2.5). When overgrowth was defined as FHHD > 15？mm, its incidence was 23%, and femoral osteotomy was identified as the only significant risk factor with an RR of 2.3 (CI 1.2–4.5). Overgrowth developed more frequently in patients who underwent femoral osteotomy at the age of 2 to 4 years (87%) than in the others (46%) (p = 0.04). Interpretation — Overgrowth of the affected limb is common in DDH patients. Patients who underwent femoral osteotomy, especially at the age of 2 to 4 years, may require careful follow-up because of the substantial risk for overgrowth
Staphylococcus aureus Produces Membrane-Derived Vesicles That Induce Host Cell Death
Mamata Gurung, Dong Chan Moon, Chi Won Choi, Jung Hwa Lee, Yong Chul Bae, Jungmin Kim, Yoo Chul Lee, Sung Yong Seol, Dong Taek Cho, Seung Il Kim, Je Chul Lee
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0027958
Abstract: Gram-negative bacteria produce outer membrane vesicles that play a role in the delivery of virulence factors to host cells. However, little is known about the membrane-derived vesicles (MVs) produced by Gram-positive bacteria. The present study examined the production of MVs from Staphylococcus aureus and investigated the delivery of MVs to host cells and subsequent cytotoxicity. Four S. aureus strains tested, two type strains and two clinical isolates, produced spherical nanovesicles during in vitro culture. MVs were also produced during in vivo infection of a clinical S. aureus isolate in a mouse pneumonia model. Proteomic analysis showed that 143 different proteins were identified in the S. aureus-derived MVs. S. aureus MVs were interacted with the plasma membrane of host cells via a cholesterol-rich membrane microdomain and then delivered their component protein A to host cells within 30 min. Intact S. aureus MVs induced apoptosis of HEp-2 cells in a dose-dependent manner, whereas lysed MVs neither delivered their component into the cytosol of host cells nor induced cytotoxicity. In conclusion, this study is the first report that S. aureus MVs are an important vehicle for delivery of bacterial effector molecules to host cells.
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